Missable chests

So, i've now defeated Sub Zero major boss, and gotten the Cryomancer Heart.

I have 8 keys for 12 chests, unless i get more keys somewhere.

To avoid the situation with last season, are there any chests within these unlockable areas that are completely "empty"? By that, i mean chests that just have duplicate relics/talismans and seasonal kredits with no new gear pieces or palettes. Anything i should avoid?

Don't wanna do everything 100% again like before, if i don't have to with those Kombo Trials and such! XD